Drug interactions
Canagliflozin-metformin + Hydrocortisone
Severity: Moderate
Canagliflozin-metformin and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic hydrocortisone can raise blood glucose and counteract the effect of metformin and canagliflozin. The effect depends on dose and duration and is greater with prolonged systemic use.
What this interaction means in plain words
Canagliflozin-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Hydrocortisone belongs to Endocrine.
Why it happens
Glucocorticoids increase gluconeogenesis and insulin resistance, opposing the glucose-lowering drugs.
What to do
Monitor blood glucose more closely during systemic corticosteroid therapy and adjust antidiabetic doses as needed, reducing them again after tapering.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Canagliflozin-metformin and Hydrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Canagliflozin-metformin
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Canagliflozin-metformin with Hydrocortisone?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic hydrocortisone can raise blood glucose and counteract the effect of metformin and canagliflozin. The effect depends on dose and duration and is greater with prolonged systemic use.
How serious is the interaction between Canagliflozin-metformin and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely during systemic corticosteroid therapy and adjust antidiabetic doses as needed, reducing them again after tapering.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
