Drug interactions
Canagliflozin-metformin + Ibuprofen / famotidine
Severity: Moderate
Canagliflozin-metformin and Ibuprofen / famotidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine may reduce renal tubular secretion of metformin and raise its levels slightly. NSAIDs such as ibuprofen can impair renal function, particularly alongside canagliflozin, which may further increase metformin exposure and the risk of lactic acidosis.
What this interaction means in plain words
Canagliflozin-metformin and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular transporters (OCT2/MATE) by famotidine, plus NSAID-related reduction in renal perfusion.
What to do
Monitor renal function and hydration, use the lowest effective NSAID dose for the shortest time, and watch for lactic acidosis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Ibuprofen / famotidine?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Ibuprofen / famotidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Famotidine may reduce renal tubular secretion of metformin and raise its levels slightly. NSAIDs such as ibuprofen can impair renal function, particularly alongside canagliflozin, which may further increase metformin exposure and the risk of lactic acidosis.
How serious is the interaction between Canagliflozin-metformin and Ibuprofen / famotidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and hydration, use the lowest effective NSAID dose for the shortest time, and watch for lactic acidosis symptoms.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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