Drug interactions
Canagliflozin-metformin + Indinavir
Severity: Moderate
Canagliflozin-metformin and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors such as indinavir have been associated with insulin resistance and hyperglycemia, and can worsen existing diabetes. Glycemic control on canagliflozin-metformin may therefore deteriorate.
What this interaction means in plain words
Canagliflozin-metformin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitors can impair insulin-mediated glucose uptake and cause insulin resistance, which opposes the glucose-lowering effect of the antidiabetic drugs.
What to do
Monitor blood glucose and HbA1c after indinavir is started or changed. Increase the antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Indinavir?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors such as indinavir have been associated with insulin resistance and hyperglycemia, and can worsen existing diabetes. Glycemic control on canagliflozin-metformin may therefore deteriorate.
How serious is the interaction between Canagliflozin-metformin and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after indinavir is started or changed. Increase the antidiabetic therapy as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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