Drug interactions
Canagliflozin-metformin + Isoniazid
Severity: Minor
Canagliflozin-metformin and Isoniazid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid can impair glucose tolerance and cause hyperglycemia, which may reduce the effectiveness of canagliflozin-metformin. Glycemic control may deteriorate during tuberculosis therapy.
What this interaction means in plain words
Canagliflozin-metformin and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Canagliflozin-metformin belongs to Endocrine; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid may impair carbohydrate metabolism and glucose tolerance; the mechanism is not well established.
What to do
Monitor blood glucose during isoniazid therapy and adjust antidiabetic doses as needed. Recheck glucose after isoniazid is stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Other interactions of Isoniazid
Frequently asked questions
Can I take Canagliflozin-metformin with Isoniazid?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Isoniazid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isoniazid can impair glucose tolerance and cause hyperglycemia, which may reduce the effectiveness of canagliflozin-metformin. Glycemic control may deteriorate during tuberculosis therapy.
How serious is the interaction between Canagliflozin-metformin and Isoniazid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during isoniazid therapy and adjust antidiabetic doses as needed. Recheck glucose after isoniazid is stopped.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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