Drug interactions
Canagliflozin-metformin + Levonorgestrel intrauterine
Severity: Minor
Canagliflozin-metformin and Levonorgestrel intrauterine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The intrauterine system releases levonorgestrel locally, with very low systemic exposure and little effect on glucose metabolism. A meaningful interaction with the antidiabetic drugs is not expected.
What this interaction means in plain words
Canagliflozin-metformin and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progestins can slightly reduce glucose tolerance, but systemic exposure from the intrauterine system is minimal.
What to do
No action is needed beyond routine glycemic monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Levonorgestrel intrauterine?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Levonorgestrel intrauterine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The intrauterine system releases levonorgestrel locally, with very low systemic exposure and little effect on glucose metabolism. A meaningful interaction with the antidiabetic drugs is not expected.
How serious is the interaction between Canagliflozin-metformin and Levonorgestrel intrauterine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is needed beyond routine glycemic monitoring.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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