Drug interactions
Canagliflozin-metformin + Liotrix
Severity: Moderate
Canagliflozin-metformin and Liotrix: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liotrix contains thyroid hormones that can raise blood glucose and increase antidiabetic requirements. Glycemic control may worsen when it is started or the dose is increased.
What this interaction means in plain words
Canagliflozin-metformin and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thyroid hormone increases hepatic glucose output, gut glucose absorption and metabolic rate, opposing antidiabetic therapy.
What to do
Monitor blood glucose when starting or changing the liotrix dose. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Liotrix?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Liotrix can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Liotrix contains thyroid hormones that can raise blood glucose and increase antidiabetic requirements. Glycemic control may worsen when it is started or the dose is increased.
How serious is the interaction between Canagliflozin-metformin and Liotrix?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the liotrix dose. Adjust antidiabetic therapy as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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