Drug interactions
Canagliflozin-metformin + Niacin
Severity: Moderate
Canagliflozin-metformin and Niacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Niacin at lipid-lowering doses causes insulin resistance and raises blood glucose. This can reduce the glycemic control achieved with canagliflozin-metformin.
What this interaction means in plain words
Canagliflozin-metformin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Niacin belongs to Cardiovascular.
Why it happens
Niacin impairs insulin sensitivity and increases hepatic glucose output, opposing the effects of the antidiabetic drugs.
What to do
Check blood glucose and HbA1c after niacin is started or its dose is raised, and adjust the antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Niacin
- Alogliptin-metformin + Niacin Moderate
- Atorvastatin + Niacin Moderate
- Cholestyramine + Niacin Moderate
- Colestipol + Niacin Moderate
- Dapagliflozin-metformin + Niacin Moderate
- Empagliflozin-metformin + Niacin Moderate
Frequently asked questions
Can I take Canagliflozin-metformin with Niacin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Niacin at lipid-lowering doses causes insulin resistance and raises blood glucose. This can reduce the glycemic control achieved with canagliflozin-metformin.
How serious is the interaction between Canagliflozin-metformin and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose and HbA1c after niacin is started or its dose is raised, and adjust the antidiabetic therapy as needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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