Drug interactions
Canagliflozin-metformin + Olmesartan
Severity: Moderate
Canagliflozin-metformin and Olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Angiotensin receptor blockers raise serum potassium and can reduce renal function, particularly with volume depletion from canagliflozin. Combined use may increase the risk of hyperkalemia and acute kidney injury, which also raises the risk of metformin accumulation.
What this interaction means in plain words
Canagliflozin-metformin and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Olmesartan belongs to Cardiovascular.
Why it happens
ARB-induced reduction of aldosterone effect with additive hemodynamic renal effects from SGLT2 inhibition.
What to do
Check potassium, creatinine and volume status after starting or adjusting therapy. Reassess metformin if eGFR declines markedly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Olmesartan
- Aliskiren + Olmesartan Contraindicated
- Olmesartan + Sparsentan Contraindicated
- Aldesleukin + Olmesartan Major
- Amifostine + Olmesartan Major
- Amiloride + Olmesartan Major
- Amlodipine-benazepril + Olmesartan Major
Frequently asked questions
Can I take Canagliflozin-metformin with Olmesartan?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Angiotensin receptor blockers raise serum potassium and can reduce renal function, particularly with volume depletion from canagliflozin. Combined use may increase the risk of hyperkalemia and acute kidney injury, which also raises the risk of metformin accumulation.
How serious is the interaction between Canagliflozin-metformin and Olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium, creatinine and volume status after starting or adjusting therapy. Reassess metformin if eGFR declines markedly.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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