Drug interactions
Canagliflozin-metformin + Perindopril
Severity: Moderate
Canagliflozin-metformin and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may improve insulin sensitivity and occasionally cause hypoglycemia with antidiabetic drugs. Perindopril can also raise potassium and reduce renal function, especially with canagliflozin-related volume depletion, which raises the risk of metformin accumulation.
What this interaction means in plain words
Canagliflozin-metformin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Perindopril belongs to Cardiovascular.
Why it happens
Additive effects on glucose, potassium and renal hemodynamics; reduced renal function limits metformin clearance.
What to do
Monitor potassium, renal function and blood glucose after initiation or dose changes. Hold metformin if acute kidney injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Frequently asked questions
Can I take Canagliflozin-metformin with Perindopril?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may improve insulin sensitivity and occasionally cause hypoglycemia with antidiabetic drugs. Perindopril can also raise potassium and reduce renal function, especially with canagliflozin-related volume depletion, which raises the risk of metformin accumulation.
How serious is the interaction between Canagliflozin-metformin and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium, renal function and blood glucose after initiation or dose changes. Hold metformin if acute kidney injury develops.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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