Drug interactions
Canagliflozin-metformin + Phenobarbital
Severity: Moderate
Canagliflozin-metformin and Phenobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenobarbital is an inducer of UGT enzymes and lowers canagliflozin exposure, which may reduce glucose-lowering efficacy. Labeling suggests a dose increase may be considered in patients with adequate renal function.
What this interaction means in plain words
Canagliflozin-metformin and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of UGT-mediated glucuronidation increases canagliflozin clearance.
What to do
Monitor glycemic control. If 100 mg canagliflozin is tolerated and eGFR is above 60, consider increasing to 300 mg; otherwise consider another agent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Phenobarbital?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Phenobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenobarbital is an inducer of UGT enzymes and lowers canagliflozin exposure, which may reduce glucose-lowering efficacy. Labeling suggests a dose increase may be considered in patients with adequate renal function.
How serious is the interaction between Canagliflozin-metformin and Phenobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control. If 100 mg canagliflozin is tolerated and eGFR is above 60, consider increasing to 300 mg; otherwise consider another agent.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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