Drug interactions
Canagliflozin-metformin + Phenytoin
Severity: Moderate
Canagliflozin-metformin and Phenytoin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin can raise blood glucose by inhibiting insulin release. It also induces UGT enzymes and lowers canagliflozin exposure, which may reduce glycemic efficacy.
What this interaction means in plain words
Canagliflozin-metformin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Canagliflozin-metformin belongs to Endocrine; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin inhibits insulin secretion and induces UGT-mediated canagliflozin metabolism.
What to do
Monitor glucose control; the canagliflozin dose may be increased if eGFR permits per labeling, or another agent considered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Frequently asked questions
Can I take Canagliflozin-metformin with Phenytoin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Phenytoin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenytoin can raise blood glucose by inhibiting insulin release. It also induces UGT enzymes and lowers canagliflozin exposure, which may reduce glycemic efficacy.
How serious is the interaction between Canagliflozin-metformin and Phenytoin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose control; the canagliflozin dose may be increased if eGFR permits per labeling, or another agent considered.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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