Drug interactions
Canagliflozin-metformin + Progesterone intravaginal
Severity: Minor
Canagliflozin-metformin and Progesterone intravaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestogens can reduce insulin sensitivity, but systemic exposure from vaginal progesterone is limited and the effect on glucose control is usually small. Clinically significant loss of control is unlikely.
What this interaction means in plain words
Canagliflozin-metformin and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone may mildly reduce insulin sensitivity, opposing the antidiabetic effect.
What to do
Monitor blood glucose when starting or stopping therapy; no routine dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Progesterone intravaginal?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Progesterone intravaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestogens can reduce insulin sensitivity, but systemic exposure from vaginal progesterone is limited and the effect on glucose control is usually small. Clinically significant loss of control is unlikely.
How serious is the interaction between Canagliflozin-metformin and Progesterone intravaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping therapy; no routine dose change is needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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