Drug interactions
Canagliflozin-metformin + Progesterone micronized
Severity: Minor
Canagliflozin-metformin and Progesterone micronized: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral micronized progesterone may modestly reduce insulin sensitivity and so weaken the effect of antidiabetic drugs. Clinically relevant changes are uncommon, but glucose may rise in some patients.
What this interaction means in plain words
Canagliflozin-metformin and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Progesterone-related decrease in insulin sensitivity opposes glucose-lowering therapy.
What to do
Monitor blood glucose when starting or stopping progesterone and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Progesterone micronized?
MediHelp rates the interaction as minor. Canagliflozin-metformin and Progesterone micronized have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral micronized progesterone may modestly reduce insulin sensitivity and so weaken the effect of antidiabetic drugs. Clinically relevant changes are uncommon, but glucose may rise in some patients.
How serious is the interaction between Canagliflozin-metformin and Progesterone micronized?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping progesterone and adjust antidiabetic therapy if needed.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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