Drug interactions
Canagliflozin-metformin + Quinapril
Severity: Moderate
Canagliflozin-metformin and Quinapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can raise potassium, and canagliflozin may add to this, especially in renal impairment. Both canagliflozin and ACE inhibitors can cause volume depletion and acute kidney injury, which increases the risk of metformin accumulation and lactic acidosis. ACE inhibitors may also enhance insulin sensitivity and cause hypoglycemia.
What this interaction means in plain words
Canagliflozin-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potassium retention and hemodynamic renal effects, with possible enhanced insulin sensitivity from ACE inhibition.
What to do
Monitor serum potassium, renal function and volume status, particularly at initiation. Hold metformin during acute kidney injury or dehydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Quinapril?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Quinapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can raise potassium, and canagliflozin may add to this, especially in renal impairment. Both canagliflozin and ACE inhibitors can cause volume depletion and acute kidney injury, which increases the risk of metformin accumulation and lactic acidosis. ACE inhibitors may also enhance insulin sensitivity and cause hypoglycemia.
How serious is the interaction between Canagliflozin-metformin and Quinapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and volume status, particularly at initiation. Hold metformin during acute kidney injury or dehydration.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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