Drug interactions
Canagliflozin-metformin + Rifampin
Severity: Moderate
Canagliflozin-metformin and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampin induces UGT enzymes and lowers canagliflozin exposure, which can reduce glycemic efficacy. The reduction is clinically meaningful enough that labeling advises considering a dose increase.
What this interaction means in plain words
Canagliflozin-metformin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of UGT-mediated glucuronidation increases canagliflozin clearance.
What to do
Monitor glycemic control. If 100 mg canagliflozin is tolerated and eGFR is above 60, consider increasing to 300 mg; otherwise use another antidiabetic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Rifampin?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifampin induces UGT enzymes and lowers canagliflozin exposure, which can reduce glycemic efficacy. The reduction is clinically meaningful enough that labeling advises considering a dose increase.
How serious is the interaction between Canagliflozin-metformin and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glycemic control. If 100 mg canagliflozin is tolerated and eGFR is above 60, consider increasing to 300 mg; otherwise use another antidiabetic.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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