Drug interactions
Canagliflozin-metformin + Sacubitril / valsartan
Severity: Moderate
Canagliflozin-metformin and Sacubitril / valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valsartan can raise serum potassium, and canagliflozin may add to this effect, especially in renal impairment. Both can also cause volume depletion and affect renal function, which increases the risk of metformin accumulation.
What this interaction means in plain words
Canagliflozin-metformin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on potassium retention and renal hemodynamics.
What to do
Monitor serum potassium, renal function and volume status after starting or adjusting therapy. Hold metformin in acute kidney injury.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Sacubitril / valsartan?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Sacubitril / valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valsartan can raise serum potassium, and canagliflozin may add to this effect, especially in renal impairment. Both can also cause volume depletion and affect renal function, which increases the risk of metformin accumulation.
How serious is the interaction between Canagliflozin-metformin and Sacubitril / valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, renal function and volume status after starting or adjusting therapy. Hold metformin in acute kidney injury.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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