Drug interactions
Canagliflozin-metformin + Tenofovir df
Severity: Moderate
Canagliflozin-metformin and Tenofovir df: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir DF can cause renal tubular toxicity and reduce renal function, which may reduce metformin elimination. Accumulation increases the risk of lactic acidosis. Canagliflozin also depends on renal function for glycemic effect.
What this interaction means in plain words
Canagliflozin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Tenofovir-related nephrotoxicity reduces renal clearance of metformin; tenofovir may also compete for renal tubular transport.
What to do
Monitor renal function regularly and review metformin dosing. Stop metformin if eGFR falls below the labeled threshold.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Canagliflozin-metformin
Frequently asked questions
Can I take Canagliflozin-metformin with Tenofovir df?
MediHelp rates the interaction as moderate. Canagliflozin-metformin and Tenofovir df can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tenofovir DF can cause renal tubular toxicity and reduce renal function, which may reduce metformin elimination. Accumulation increases the risk of lactic acidosis. Canagliflozin also depends on renal function for glycemic effect.
How serious is the interaction between Canagliflozin-metformin and Tenofovir df?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function regularly and review metformin dosing. Stop metformin if eGFR falls below the labeled threshold.
What other medicines interact with Canagliflozin-metformin?
MediHelp also lists interactions of Canagliflozin-metformin with, for example, Contrast media, Diatrizoate, Diatrizoate meglumine / diatrizoate. The full list is on the Canagliflozin-metformin page.
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