Drug interactions
Candesartan + Carbenoxolone
Severity: Moderate
Candesartan and Carbenoxolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium retention, hypokalemia and hypertension, which opposes candesartan's effects. Fluid retention and electrolyte disturbances can result.
What this interaction means in plain words
Candesartan and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, producing mineralocorticoid effects that counter the antihypertensive and potassium-sparing action of ARBs.
What to do
Monitor blood pressure, fluid status and serum potassium; consider alternative gastric therapy where feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Carbenoxolone?
MediHelp rates the interaction as moderate. Candesartan and Carbenoxolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity causing sodium retention, hypokalemia and hypertension, which opposes candesartan's effects. Fluid retention and electrolyte disturbances can result.
How serious is the interaction between Candesartan and Carbenoxolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium; consider alternative gastric therapy where feasible.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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