Drug interactions
Candesartan + Carvedilol
Severity: Moderate
Candesartan and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan and carvedilol together lower blood pressure additively, and the combination is used in heart failure. Hypotension and hyperkalemia may occur, and candesartan is fetotoxic in pregnancy.
What this interaction means in plain words
Candesartan and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Carvedilol belongs to Cardiovascular.
Why it happens
Additive hemodynamic effects of angiotensin receptor blockade and adrenergic blockade, with candesartan-related potassium retention.
What to do
Monitor blood pressure, potassium and renal function when starting or adjusting doses. Avoid candesartan in pregnancy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Carvedilol?
MediHelp rates the interaction as moderate. Candesartan and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Candesartan and carvedilol together lower blood pressure additively, and the combination is used in heart failure. Hypotension and hyperkalemia may occur, and candesartan is fetotoxic in pregnancy.
How serious is the interaction between Candesartan and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, potassium and renal function when starting or adjusting doses. Avoid candesartan in pregnancy.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Albuterol, Amifostine, Amiodarone. The full list is on the Carvedilol page.
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