Drug interactions
Candesartan + Choline magnesium trisalicylate
Severity: Moderate
Candesartan and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates at anti-inflammatory doses may blunt candesartan's antihypertensive effect and impair renal function, particularly in volume-depleted or older patients. Hyperkalemia is possible.
What this interaction means in plain words
Candesartan and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal blood flow and potassium excretion, opposing ARB action.
What to do
Monitor blood pressure, creatinine and potassium, and ensure hydration. Use the lowest effective salicylate dose or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Candesartan and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates at anti-inflammatory doses may blunt candesartan's antihypertensive effect and impair renal function, particularly in volume-depleted or older patients. Hyperkalemia is possible.
How serious is the interaction between Candesartan and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, creatinine and potassium, and ensure hydration. Use the lowest effective salicylate dose or an alternative analgesic.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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