Drug interactions
Candesartan + Fenoprofen
Severity: Moderate
Candesartan and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoprofen can blunt the antihypertensive effect of candesartan. Together they can impair renal function and raise potassium, especially in elderly, volume-depleted or renally impaired patients.
What this interaction means in plain words
Candesartan and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces glomerular perfusion while angiotensin receptor blockade reduces efferent arteriolar tone, impairing filtration.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID. Avoid the combination in high-risk patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Fenoprofen?
MediHelp rates the interaction as moderate. Candesartan and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoprofen can blunt the antihypertensive effect of candesartan. Together they can impair renal function and raise potassium, especially in elderly, volume-depleted or renally impaired patients.
How serious is the interaction between Candesartan and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting the NSAID. Avoid the combination in high-risk patients where possible.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
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