Drug interactions
Candesartan + Heparin
Severity: Moderate
Candesartan and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress adrenal aldosterone synthesis and cause hyperkalemia, even at modest doses over several days. Together with candesartan the risk of raised potassium is greater, mostly in diabetes, renal impairment or acidosis.
What this interaction means in plain words
Candesartan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of aldosterone synthesis adds to ARB blockade of angiotensin II-driven aldosterone effects.
What to do
Monitor serum potassium in patients on prolonged heparin therapy and in those with renal impairment or diabetes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Candesartan with Heparin?
MediHelp rates the interaction as moderate. Candesartan and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress adrenal aldosterone synthesis and cause hyperkalemia, even at modest doses over several days. Together with candesartan the risk of raised potassium is greater, mostly in diabetes, renal impairment or acidosis.
How serious is the interaction between Candesartan and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on prolonged heparin therapy and in those with renal impairment or diabetes.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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