Drug interactions
Candesartan + Indapamide
Severity: Moderate
Candesartan and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination provides additive blood pressure lowering. Candesartan tends to raise potassium and indapamide lowers it, so the effects may offset each other, but hypotension and renal impairment can occur with volume depletion.
What this interaction means in plain words
Candesartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Candesartan belongs to Cardiovascular; Indapamide belongs to Cardiovascular.
Why it happens
Additive antihypertensive effect, with opposing effects on potassium excretion via angiotensin receptor blockade and diuretic-induced kaliuresis.
What to do
Monitor blood pressure, serum potassium and creatinine after initiation or dose changes. Watch for hypotension in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indapamide
Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Indapamide?
MediHelp rates the interaction as moderate. Candesartan and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination provides additive blood pressure lowering. Candesartan tends to raise potassium and indapamide lowers it, so the effects may offset each other, but hypotension and renal impairment can occur with volume depletion.
How serious is the interaction between Candesartan and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after initiation or dose changes. Watch for hypotension in volume-depleted patients.
What other medicines interact with Indapamide?
MediHelp also lists interactions of Indapamide with, for example, Adagrasib, Amifostine, Amiodarone. The full list is on the Indapamide page.
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