Drug interactions
Candesartan + Insulin degludec / insulin aspart
Severity: Moderate
Candesartan and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan may enhance insulin sensitivity and thus add to the glucose-lowering effect of insulin, occasionally causing hypoglycemia. The effect is usually modest.
What this interaction means in plain words
Candesartan and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ARB-mediated improvement in insulin sensitivity adds to insulin's glucose-lowering effect; the exact mechanism is not fully established.
What to do
Monitor blood glucose more closely when starting or adjusting candesartan, and lower the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Candesartan and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Candesartan may enhance insulin sensitivity and thus add to the glucose-lowering effect of insulin, occasionally causing hypoglycemia. The effect is usually modest.
How serious is the interaction between Candesartan and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more closely when starting or adjusting candesartan, and lower the insulin dose if hypoglycemia occurs.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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