Drug interactions
Candesartan + Meclofenamate
Severity: Moderate
Candesartan and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meclofenamate can reduce the antihypertensive effect of candesartan and, together with an ARB, increases the risk of acute kidney injury and hyperkalemia. The risk is highest in older patients, those with volume depletion or existing renal impairment.
What this interaction means in plain words
Candesartan and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal perfusion and sodium excretion, while ARB blockade impairs efferent arteriolar tone, compromising glomerular filtration.
What to do
Use the lowest effective NSAID dose for the shortest time, ensure adequate hydration, and monitor blood pressure, creatinine and potassium. Consider an alternative analgesic in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Meclofenamate?
MediHelp rates the interaction as moderate. Candesartan and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meclofenamate can reduce the antihypertensive effect of candesartan and, together with an ARB, increases the risk of acute kidney injury and hyperkalemia. The risk is highest in older patients, those with volume depletion or existing renal impairment.
How serious is the interaction between Candesartan and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective NSAID dose for the shortest time, ensure adequate hydration, and monitor blood pressure, creatinine and potassium. Consider an alternative analgesic in high-risk patients.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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