Drug interactions
Candesartan + Nitroglycerin rectal
Severity: Moderate
Candesartan and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin is a potent vasodilator, and combined with candesartan it can cause additive hypotension, dizziness, or syncope. Risk is greater in volume-depleted or elderly patients.
What this interaction means in plain words
Candesartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitric oxide-mediated venodilation and angiotensin II receptor blockade.
What to do
Monitor blood pressure and advise patients to rise slowly; reduce the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Candesartan and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin is a potent vasodilator, and combined with candesartan it can cause additive hypotension, dizziness, or syncope. Risk is greater in volume-depleted or elderly patients.
How serious is the interaction between Candesartan and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and advise patients to rise slowly; reduce the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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