Drug interactions
Candesartan + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Candesartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paritaprevir inhibits transporters such as OATP1B1/1B3, which may increase candesartan exposure, with the risk of hypotension, hyperkalemia, or worsened renal function. The exact magnitude for candesartan is not well characterized.
What this interaction means in plain words
Candesartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable inhibition of hepatic uptake transporters by paritaprevir and ritonavir, raising candesartan concentrations; mechanism not fully established.
What to do
Consider reducing the candesartan dose and monitor blood pressure, renal function and potassium during the antiviral course. Reduce further or switch agents if hypotension or renal deterioration occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Candesartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paritaprevir inhibits transporters such as OATP1B1/1B3, which may increase candesartan exposure, with the risk of hypotension, hyperkalemia, or worsened renal function. The exact magnitude for candesartan is not well characterized.
How serious is the interaction between Candesartan and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing the candesartan dose and monitor blood pressure, renal function and potassium during the antiviral course. Reduce further or switch agents if hypotension or renal deterioration occurs.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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