Drug interactions
Candesartan + Sacubitril / valsartan
Severity: Major
Candesartan and Sacubitril / valsartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using two angiotensin receptor blockers together gives no added benefit and increases the risk of hypotension, hyperkalemia, and renal impairment. Sacubitril/valsartan already provides full angiotensin receptor blockade.
What this interaction means in plain words
Candesartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Duplicate angiotensin II type 1 receptor blockade produces additive effects on blood pressure, aldosterone suppression and renal hemodynamics.
What to do
Avoid combining; stop candesartan when sacubitril/valsartan is used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Sacubitril / valsartan?
MediHelp rates the interaction as major. Candesartan and Sacubitril / valsartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Using two angiotensin receptor blockers together gives no added benefit and increases the risk of hypotension, hyperkalemia, and renal impairment. Sacubitril/valsartan already provides full angiotensin receptor blockade.
How serious is the interaction between Candesartan and Sacubitril / valsartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; stop candesartan when sacubitril/valsartan is used.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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