Drug interactions
Candesartan + Sulfasalazine
Severity: Minor
Candesartan and Sulfasalazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine has minimal NSAID-like systemic effects on renal prostaglandins, so a clinically meaningful interaction with candesartan is not well established. The legacy concern appears to be extrapolated from NSAIDs rather than sulfasalazine itself.
What this interaction means in plain words
Candesartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established mechanism; any effect would be theoretical extrapolation from NSAID class effects.
What to do
No specific action is needed beyond routine monitoring of renal function and potassium in patients on candesartan.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Sulfasalazine?
MediHelp rates the interaction as minor. Candesartan and Sulfasalazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfasalazine has minimal NSAID-like systemic effects on renal prostaglandins, so a clinically meaningful interaction with candesartan is not well established. The legacy concern appears to be extrapolated from NSAIDs rather than sulfasalazine itself.
How serious is the interaction between Candesartan and Sulfasalazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine monitoring of renal function and potassium in patients on candesartan.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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