Drug interactions
Candesartan + Synthetic human angiotensin ii
Severity: Moderate
Candesartan and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Candesartan blocks the AT1 receptor and can blunt the pressor effect of exogenous angiotensin II, so higher doses may be required to treat vasodilatory shock in patients taking an ARB. Hypotension may be more resistant to therapy.
What this interaction means in plain words
Candesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive antagonism at the angiotensin II type 1 receptor.
What to do
Titrate angiotensin II to blood pressure response, expecting that higher doses may be needed, and consider the long half-life of candesartan when assessing response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Candesartan
- Aliskiren + Candesartan Contraindicated
- Candesartan + Sparsentan Contraindicated
- Amifostine + Candesartan Major
- Amiloride + Candesartan Major
- Amlodipine-benazepril + Candesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Major
Frequently asked questions
Can I take Candesartan with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Candesartan and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Candesartan blocks the AT1 receptor and can blunt the pressor effect of exogenous angiotensin II, so higher doses may be required to treat vasodilatory shock in patients taking an ARB. Hypotension may be more resistant to therapy.
How serious is the interaction between Candesartan and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate angiotensin II to blood pressure response, expecting that higher doses may be needed, and consider the long half-life of candesartan when assessing response.
What other medicines interact with Candesartan?
MediHelp also lists interactions of Candesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Candesartan page.
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