Drug interactions
Cannabidiol + Carisoprodol
Severity: Moderate
Cannabidiol and Carisoprodol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19, which converts carisoprodol to meprobamate. This may raise carisoprodol exposure, and cannabidiol itself causes somnolence, so sedation may increase.
What this interaction means in plain words
Cannabidiol and Carisoprodol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Carisoprodol belongs to Musculoskeletal.
Why it happens
Cannabidiol inhibits CYP2C19 metabolism of carisoprodol and adds pharmacodynamic CNS depression.
What to do
Monitor for excess sedation and dizziness. Consider lowering the carisoprodol dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carisoprodol
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Carisoprodol?
MediHelp rates the interaction as moderate. Cannabidiol and Carisoprodol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19, which converts carisoprodol to meprobamate. This may raise carisoprodol exposure, and cannabidiol itself causes somnolence, so sedation may increase.
How serious is the interaction between Cannabidiol and Carisoprodol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness. Consider lowering the carisoprodol dose if symptoms occur.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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