Drug interactions
Cannabidiol + Cyclobenzaprine
Severity: Moderate
Cannabidiol and Cyclobenzaprine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is partly metabolized by CYP1A2, which cannabidiol may inhibit or induce in vitro. Exposure to cyclobenzaprine could change, and additive sedation is also possible.
What this interaction means in plain words
Cannabidiol and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Cyclobenzaprine belongs to Musculoskeletal.
Why it happens
Possible modulation of CYP1A2 (and CYP3A4/2D6) metabolism of cyclobenzaprine plus additive CNS depression.
What to do
Monitor for sedation, anticholinergic effects and reduced effect when starting or changing cannabidiol. Adjust cyclobenzaprine dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Cyclobenzaprine?
MediHelp rates the interaction as moderate. Cannabidiol and Cyclobenzaprine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is partly metabolized by CYP1A2, which cannabidiol may inhibit or induce in vitro. Exposure to cyclobenzaprine could change, and additive sedation is also possible.
How serious is the interaction between Cannabidiol and Cyclobenzaprine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, anticholinergic effects and reduced effect when starting or changing cannabidiol. Adjust cyclobenzaprine dose as needed.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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