Drug interactions
Cannabidiol + Dacarbazine
Severity: Minor
Cannabidiol and Dacarbazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacarbazine is partly metabolized by CYP1A2 to its active form, and cannabidiol can both inhibit and induce this enzyme. The net effect on dacarbazine exposure and activity is unpredictable, with a possible change in efficacy or toxicity.
What this interaction means in plain words
Cannabidiol and Dacarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Dacarbazine belongs to Oncology.
Why it happens
Cannabidiol has mixed CYP1A2 inhibitory and inducing effects that may alter dacarbazine metabolism.
What to do
Monitor blood counts and tumor response, and watch for dacarbazine toxicity. Adjust therapy based on clinical findings.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dacarbazine
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Dacarbazine?
MediHelp rates the interaction as minor. Cannabidiol and Dacarbazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dacarbazine is partly metabolized by CYP1A2 to its active form, and cannabidiol can both inhibit and induce this enzyme. The net effect on dacarbazine exposure and activity is unpredictable, with a possible change in efficacy or toxicity.
How serious is the interaction between Cannabidiol and Dacarbazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and tumor response, and watch for dacarbazine toxicity. Adjust therapy based on clinical findings.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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