Drug interactions
Cannabidiol + Diltiazem
Severity: Moderate
Cannabidiol and Diltiazem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diltiazem may increase cannabidiol concentrations through CYP3A4 inhibition. This can increase sedation, somnolence and other adverse effects of cannabidiol.
What this interaction means in plain words
Cannabidiol and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Diltiazem belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 (a pathway of cannabidiol metabolism) by diltiazem reduces cannabidiol clearance.
What to do
Monitor for sedation and other cannabidiol adverse effects, and reduce the cannabidiol dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Diltiazem?
MediHelp rates the interaction as moderate. Cannabidiol and Diltiazem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diltiazem may increase cannabidiol concentrations through CYP3A4 inhibition. This can increase sedation, somnolence and other adverse effects of cannabidiol.
How serious is the interaction between Cannabidiol and Diltiazem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and other cannabidiol adverse effects, and reduce the cannabidiol dose if they occur.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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