Drug interactions
Cannabidiol + Divalproex
Severity: Moderate
Cannabidiol and Divalproex: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking cannabidiol with valproate is associated with a higher frequency of raised liver transaminases than either drug alone. Elevations are usually reversible but may need dose adjustment or discontinuation. Cannabidiol may also increase somnolence and reduce appetite.
What this interaction means in plain words
Cannabidiol and Divalproex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism is not firmly established; additive hepatotoxic potential is suspected.
What to do
Check liver enzymes and bilirubin before starting and periodically during treatment. Reduce the dose of one or both drugs or stop if transaminases rise significantly, especially above three times the upper limit of normal with symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Divalproex?
MediHelp rates the interaction as moderate. Cannabidiol and Divalproex can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking cannabidiol with valproate is associated with a higher frequency of raised liver transaminases than either drug alone. Elevations are usually reversible but may need dose adjustment or discontinuation. Cannabidiol may also increase somnolence and reduce appetite.
How serious is the interaction between Cannabidiol and Divalproex?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver enzymes and bilirubin before starting and periodically during treatment. Reduce the dose of one or both drugs or stop if transaminases rise significantly, especially above three times the upper limit of normal with symptoms.
What other medicines interact with Cannabidiol?
MediHelp also lists interactions of Cannabidiol with, for example, Phenytoin, Sodium valproate, Tacrolimus. The full list is on the Cannabidiol page.
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