Drug interactions
Cannabidiol + Esketamine
Severity: Moderate
Cannabidiol and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol causes somnolence and sedation and may add to esketamine sedation and dizziness. Cannabidiol also inhibits some CYP enzymes, although a meaningful effect on esketamine has not been established.
What this interaction means in plain words
Cannabidiol and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression; possible minor metabolic effects.
What to do
Monitor for oversedation and impaired alertness after esketamine dosing and reduce the cannabidiol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Esketamine?
MediHelp rates the interaction as moderate. Cannabidiol and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol causes somnolence and sedation and may add to esketamine sedation and dizziness. Cannabidiol also inhibits some CYP enzymes, although a meaningful effect on esketamine has not been established.
How serious is the interaction between Cannabidiol and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and impaired alertness after esketamine dosing and reduce the cannabidiol dose if needed.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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