Drug interactions
Cannabidiol + Isoniazid
Severity: Moderate
Cannabidiol and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isoniazid inhibits CYP2C19 and CYP3A4, both of which metabolize cannabidiol and its active metabolite. Cannabidiol exposure may increase, causing somnolence, sedation and liver enzyme elevation. Additive hepatotoxicity with isoniazid is also a concern.
What this interaction means in plain words
Cannabidiol and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid inhibition of CYP2C19 and CYP3A4 decreases cannabidiol clearance.
What to do
Monitor liver enzymes and for sedation, and reduce the cannabidiol dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Isoniazid?
MediHelp rates the interaction as moderate. Cannabidiol and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isoniazid inhibits CYP2C19 and CYP3A4, both of which metabolize cannabidiol and its active metabolite. Cannabidiol exposure may increase, causing somnolence, sedation and liver enzyme elevation. Additive hepatotoxicity with isoniazid is also a concern.
How serious is the interaction between Cannabidiol and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and for sedation, and reduce the cannabidiol dose if adverse effects occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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