Drug interactions
Cannabidiol + Ketamine
Severity: Minor
Cannabidiol and Ketamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol has sedative effects and may add to ketamine's CNS effects. Cannabidiol inhibits several CYP enzymes, which might modestly raise ketamine exposure.
What this interaction means in plain words
Cannabidiol and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS effects and possible CYP inhibition by cannabidiol reducing ketamine metabolism.
What to do
Titrate ketamine to effect and monitor sedation level. Lower the dose if excessive drowsiness occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketamine
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Ketamine?
MediHelp rates the interaction as minor. Cannabidiol and Ketamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol has sedative effects and may add to ketamine's CNS effects. Cannabidiol inhibits several CYP enzymes, which might modestly raise ketamine exposure.
How serious is the interaction between Cannabidiol and Ketamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate ketamine to effect and monitor sedation level. Lower the dose if excessive drowsiness occurs.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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