Drug interactions
Cannabidiol + Lamotrigine
Severity: Moderate
Cannabidiol and Lamotrigine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol may raise lamotrigine concentrations because lamotrigine is cleared mainly by glucuronidation through UGT enzymes. This could increase the risk of dizziness, ataxia, diplopia, somnolence and rash.
What this interaction means in plain words
Cannabidiol and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Lamotrigine belongs to Central Nervous System.
Why it happens
Cannabidiol may inhibit UGT enzymes, including UGT2B7 and UGT1A4, which reduces lamotrigine glucuronidation.
What to do
Monitor for lamotrigine adverse effects and consider checking serum levels when cannabidiol is started or stopped. Reduce the lamotrigine dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lamotrigine
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Lamotrigine?
MediHelp rates the interaction as moderate. Cannabidiol and Lamotrigine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol may raise lamotrigine concentrations because lamotrigine is cleared mainly by glucuronidation through UGT enzymes. This could increase the risk of dizziness, ataxia, diplopia, somnolence and rash.
How serious is the interaction between Cannabidiol and Lamotrigine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lamotrigine adverse effects and consider checking serum levels when cannabidiol is started or stopped. Reduce the lamotrigine dose if toxicity appears.
What other medicines interact with Lamotrigine?
MediHelp also lists interactions of Lamotrigine with, for example, Desogestrel-ethinyl estradiol, Divalproex, Dofetilide. The full list is on the Lamotrigine page.
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