Drug interactions
Cannabidiol + Lansoprazole
Severity: Moderate
Cannabidiol and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are involved with CYP2C19: cannabidiol inhibits it and lansoprazole is a substrate, while lansoprazole may modestly raise cannabidiol levels. Exposure of either may increase, with more adverse effects such as sedation.
What this interaction means in plain words
Cannabidiol and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Mutual interference with CYP2C19-mediated metabolism, with cannabidiol inhibiting CYP2C19.
What to do
Monitor for sedation, diarrhea and other adverse effects, and consider reducing the dose of either drug if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Lansoprazole?
MediHelp rates the interaction as moderate. Cannabidiol and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are involved with CYP2C19: cannabidiol inhibits it and lansoprazole is a substrate, while lansoprazole may modestly raise cannabidiol levels. Exposure of either may increase, with more adverse effects such as sedation.
How serious is the interaction between Cannabidiol and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, diarrhea and other adverse effects, and consider reducing the dose of either drug if these occur.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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