Drug interactions
Cannabidiol + Pimozide
Severity: Moderate
Cannabidiol and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can inhibit and possibly induce CYP1A2 and other enzymes, which may change pimozide exposure. Pimozide is mainly cleared by CYP3A4 and CYP2D6 with a minor CYP1A2 contribution, and cannabidiol may also inhibit CYP2D6 and CYP3A4, so levels and QT risk could rise.
What this interaction means in plain words
Cannabidiol and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Cannabidiol inhibition of CYP enzymes (including CYP1A2, CYP3A4 and CYP2D6) that metabolize pimozide.
What to do
Monitor for pimozide adverse effects such as sedation, extrapyramidal symptoms and QT prolongation. Consider an ECG and a pimozide dose reduction if cannabidiol is started.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Pimozide?
MediHelp rates the interaction as moderate. Cannabidiol and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can inhibit and possibly induce CYP1A2 and other enzymes, which may change pimozide exposure. Pimozide is mainly cleared by CYP3A4 and CYP2D6 with a minor CYP1A2 contribution, and cannabidiol may also inhibit CYP2D6 and CYP3A4, so levels and QT risk could rise.
How serious is the interaction between Cannabidiol and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pimozide adverse effects such as sedation, extrapyramidal symptoms and QT prolongation. Consider an ECG and a pimozide dose reduction if cannabidiol is started.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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