Drug interactions
Cannabidiol + Propranolol
Severity: Minor
Cannabidiol and Propranolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is partly cleared by CYP1A2, and cannabidiol may alter CYP1A2 activity. The effect on propranolol exposure is unpredictable but may change beta-blockade intensity.
What this interaction means in plain words
Cannabidiol and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Propranolol belongs to Cardiovascular.
Why it happens
Cannabidiol may inhibit or induce CYP1A2, changing propranolol metabolism; the direction of effect is not well established.
What to do
Monitor heart rate and blood pressure when starting or stopping cannabidiol, and adjust the propranolol dose to response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Albuterol + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Propranolol?
MediHelp rates the interaction as minor. Cannabidiol and Propranolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol is partly cleared by CYP1A2, and cannabidiol may alter CYP1A2 activity. The effect on propranolol exposure is unpredictable but may change beta-blockade intensity.
How serious is the interaction between Cannabidiol and Propranolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping cannabidiol, and adjust the propranolol dose to response.
What other medicines interact with Propranolol?
MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.
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