Drug interactions
Cannabidiol + Rabeprazole
Severity: Minor
Cannabidiol and Rabeprazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19, and rabeprazole is metabolized mainly non-enzymatically with a minor CYP2C19 contribution, so the effect on rabeprazole is likely small. Rabeprazole is a weak CYP2C19 inhibitor, so the effect on cannabidiol is also expected to be small.
What this interaction means in plain words
Cannabidiol and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cannabidiol belongs to Central Nervous System; Rabeprazole belongs to Gastrointestinal Tract.
Why it happens
Possible modest CYP2C19 inhibition in both directions, with limited clinical relevance.
What to do
No routine dose change is required; monitor for sedation or adverse effects of cannabidiol and for loss of PPI effect if symptoms change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cannabidiol and Rabeprazole, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Rabeprazole?
MediHelp rates the interaction as minor. Cannabidiol and Rabeprazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabidiol inhibits CYP2C19, and rabeprazole is metabolized mainly non-enzymatically with a minor CYP2C19 contribution, so the effect on rabeprazole is likely small. Rabeprazole is a weak CYP2C19 inhibitor, so the effect on cannabidiol is also expected to be small.
How serious is the interaction between Cannabidiol and Rabeprazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is required; monitor for sedation or adverse effects of cannabidiol and for loss of PPI effect if symptoms change.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
