Drug interactions
Cannabidiol + Tofacitinib
Severity: Moderate
Cannabidiol and Tofacitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol inhibits CYP2C19 and CYP3A4 and may raise tofacitinib exposure. Higher levels could increase infection, cytopenia and lipid effects.
What this interaction means in plain words
Cannabidiol and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cannabidiol belongs to Central Nervous System; Tofacitinib belongs to Musculoskeletal.
Why it happens
Cannabidiol inhibits CYP2C19 and CYP3A4, which contribute to tofacitinib clearance.
What to do
Monitor for tofacitinib adverse effects such as infection and cytopenias. Consider reducing the tofacitinib dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Sodium valproate Major
- Cannabidiol + Tacrolimus Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Cannabidiol with Tofacitinib?
MediHelp rates the interaction as moderate. Cannabidiol and Tofacitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol inhibits CYP2C19 and CYP3A4 and may raise tofacitinib exposure. Higher levels could increase infection, cytopenia and lipid effects.
How serious is the interaction between Cannabidiol and Tofacitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tofacitinib adverse effects such as infection and cytopenias. Consider reducing the tofacitinib dose if toxicity develops.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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