Drug interactions
Capecitabine + Cedazuridine
Severity: Moderate
Capecitabine and Cedazuridine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cedazuridine inhibits cytidine deaminase, which is not the main pathway for capecitabine activation or clearance, which relies on carboxylesterase, thymidine phosphorylase and DPD. An effect on capecitabine exposure is possible for its intermediate 5'-deoxy-5-fluorocytidine, which is deaminated by CDA, but the clinical impact is uncertain.
What this interaction means in plain words
Capecitabine and Cedazuridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of cytidine deaminase may alter conversion of the capecitabine intermediate 5'-DFCR to 5'-DFUR, with unestablished clinical effect.
What to do
Avoid routine combination; if both are needed, monitor for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Cedazuridine?
MediHelp rates the interaction as moderate. Capecitabine and Cedazuridine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cedazuridine inhibits cytidine deaminase, which is not the main pathway for capecitabine activation or clearance, which relies on carboxylesterase, thymidine phosphorylase and DPD. An effect on capecitabine exposure is possible for its intermediate 5'-deoxy-5-fluorocytidine, which is deaminated by CDA, but the clinical impact is uncertain.
How serious is the interaction between Capecitabine and Cedazuridine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine combination; if both are needed, monitor for fluoropyrimidine toxicity such as diarrhea, hand-foot syndrome and myelosuppression.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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