Drug interactions
Capecitabine + Fexinidazole
Severity: Major
Capecitabine and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval, and capecitabine, through fluorouracil, has been associated with QT prolongation and rare arrhythmias. Combined use may raise the risk of serious ventricular arrhythmia.
What this interaction means in plain words
Capecitabine and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive effects on cardiac repolarization and QT prolongation.
What to do
Avoid the combination if possible; otherwise obtain a baseline and follow-up ECG and correct potassium and magnesium before and during treatment.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Fexinidazole?
MediHelp rates the interaction as major. Capecitabine and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval, and capecitabine, through fluorouracil, has been associated with QT prolongation and rare arrhythmias. Combined use may raise the risk of serious ventricular arrhythmia.
How serious is the interaction between Capecitabine and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise obtain a baseline and follow-up ECG and correct potassium and magnesium before and during treatment.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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