Drug interactions
Capecitabine + Influenza virus vaccine adjuvanted
Severity: Moderate
Capecitabine and Influenza virus vaccine adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Capecitabine can suppress immune function, which may reduce the antibody response to an adjuvanted H5N1 influenza vaccine. Protection may be incomplete in treated patients.
What this interaction means in plain words
Capecitabine and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic chemotherapy-induced immunosuppression diminishes vaccine immunogenicity.
What to do
Where possible, time vaccination before chemotherapy begins or between cycles when counts have recovered. Do not rely on the vaccine alone for protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Capecitabine and Influenza virus vaccine adjuvanted, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Influenza virus vaccine adjuvanted?
MediHelp rates the interaction as moderate. Capecitabine and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Capecitabine can suppress immune function, which may reduce the antibody response to an adjuvanted H5N1 influenza vaccine. Protection may be incomplete in treated patients.
How serious is the interaction between Capecitabine and Influenza virus vaccine adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, time vaccination before chemotherapy begins or between cycles when counts have recovered. Do not rely on the vaccine alone for protection.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
