Drug interactions
Capecitabine + Influenza virus vaccine trivalent adjuvanted
Severity: Moderate
Capecitabine and Influenza virus vaccine trivalent adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytotoxic chemotherapy can blunt antibody responses to inactivated influenza vaccine. The vaccine is not harmful in this setting, but protection may be reduced.
What this interaction means in plain words
Capecitabine and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced lymphocyte suppression reduces the immune response to vaccination.
What to do
Still vaccinate patients on capecitabine since inactivated vaccine is recommended. Where possible give the vaccine before starting chemotherapy or between cycles when counts have recovered, and do not rely on a single dose for full protection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Influenza virus vaccine trivalent adjuvanted?
MediHelp rates the interaction as moderate. Capecitabine and Influenza virus vaccine trivalent adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytotoxic chemotherapy can blunt antibody responses to inactivated influenza vaccine. The vaccine is not harmful in this setting, but protection may be reduced.
How serious is the interaction between Capecitabine and Influenza virus vaccine trivalent adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Still vaccinate patients on capecitabine since inactivated vaccine is recommended. Where possible give the vaccine before starting chemotherapy or between cycles when counts have recovered, and do not rely on a single dose for full protection.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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