Drug interactions
Capecitabine + Lansoprazole
Severity: Moderate
Capecitabine and Lansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Retrospective observations suggest PPIs may be linked to poorer outcomes with capecitabine, possibly through reduced tablet dissolution at higher gastric pH. The findings are inconsistent and causality is unproven.
What this interaction means in plain words
Capecitabine and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Capecitabine belongs to Oncology; Lansoprazole belongs to Gastrointestinal Tract.
Why it happens
Possible reduced capecitabine dissolution and absorption at elevated gastric pH; not established.
What to do
Review whether the PPI is necessary and consider an H2 antagonist or stopping it if no clear indication exists. Monitor oncologic response and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lansoprazole
- Lansoprazole + Mavacamten Contraindicated
- Lansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Lansoprazole Major
- Atazanavir + Lansoprazole Major
- Dacomitinib + Lansoprazole Major
- Dasatinib + Lansoprazole Major
Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Lansoprazole?
MediHelp rates the interaction as moderate. Capecitabine and Lansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Retrospective observations suggest PPIs may be linked to poorer outcomes with capecitabine, possibly through reduced tablet dissolution at higher gastric pH. The findings are inconsistent and causality is unproven.
How serious is the interaction between Capecitabine and Lansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether the PPI is necessary and consider an H2 antagonist or stopping it if no clear indication exists. Monitor oncologic response and toxicity.
What other medicines interact with Lansoprazole?
MediHelp also lists interactions of Lansoprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Lansoprazole page.
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