Drug interactions
Capecitabine + Ofatumumab sc
Severity: Moderate
Capecitabine and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and capecitabine suppresses the bone marrow, so combined use may raise the risk of infection. The effect is additive immunosuppression.
What this interaction means in plain words
Capecitabine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and cytotoxic myelosuppression.
What to do
Monitor for signs of infection and check blood counts regularly. Consider the duration of the immune effects of prior therapy when starting ofatumumab.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Capecitabine
Frequently asked questions
Can I take Capecitabine with Ofatumumab sc?
MediHelp rates the interaction as moderate. Capecitabine and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and capecitabine suppresses the bone marrow, so combined use may raise the risk of infection. The effect is additive immunosuppression.
How serious is the interaction between Capecitabine and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts regularly. Consider the duration of the immune effects of prior therapy when starting ofatumumab.
What other medicines interact with Capecitabine?
MediHelp also lists interactions of Capecitabine with, for example, Adenovirus types 4 and 7 live, Arsenic trioxide, Axicabtagene ciloleucel. The full list is on the Capecitabine page.
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